Onsia 4mg (Ondansetron)

What exactly is Ondansetron?

Ondansetron inhibits the action of body chemicals, which can cause nausea and vomiting.

Ondansetron can be used to treat vomiting and nausea that can result from chemotherapy, surgery chemotherapy, and radiation treatment.

Ondansetron is a medication that can be used for reasons not mentioned in this guideline.

Warnings

Ondansetron should not be used when taking the apomorphine (Apokyn).

It is not recommended to take Ondansetron if you have an allergy to it or similar medicines like dolasetron (Anzemet) or the granisetron (Kytril) as well as palonosetron (Aloxi).

Before you take Ondansetron, consult your physician whether you suffer from liver disease or have a family or personal background for Long QT syndrome.

Ondansetron tablets that dissolve orally could contain Phenylalanine. Inform your physician if you suffer from a condition known as phenylketonuria (PKU).

Ondansetron can cause serious side effects. These include blurred vision, temporary loss of vision (lasting between some minutes to many hours) as well as a slower heart rate, difficulty breathing anxiety, agitation, experiencing shivering, feeling as if you’re going to pass out or urinate less frequently than normal or never at all. Take this medicine off your list and consult your physician immediately if you notice any of these adverse reactions. Ondansetron can affect your responses or thinking. Be aware when driving or doing any activity that requires you to be vigilant.

Before taking Ondansetron

It is best not to make use of Ondansetron when:

• If you’re using the drug apomorphine (Apokyn), also known as
• you are sensitive to Ondansetron or similar medications (dolasetron or granisetron).

To be sure Ondansetron is not harmful to you, consult your physician If you are suffering from:

• liver disease;
• An electrolyte imbalance (such in low concentrations of magnesium or potassium or magnesium in the blood);
• congestive heart malfunction, slow heartbeats,
• an individual or family experience of having long QT syndrome or
• An obstruction within the stomach (stomach or the intestines).

Ondansetron isn’t intended to harm the unborn baby. Inform your doctor if you are expecting.

It’s not clear if Ondansetron is absorbed into breast milk or if it can harm the nursing infant. Consult your physician if you are breastfeeding a baby.

Ondansetron is not recommended for use by anyone less than four years old.

Orally disintegrating tablets of Ondansetron could contain the chemical phenylalanine. Inform your physician if you suffer from Phenylketonuria (PKU).

What should I take Ondansetron?

You should take Ondansetron precisely as directed by your physician. Follow all the instructions on the prescription label. Don’t take this medication in greater or lesser doses or longer than prescribed.

Ondansetron is a drug that can be consumed with and without meals.

First doses are typically given prior to your chemotherapy or radiation therapy. Follow the dosing guidelines of your physician exceptionally carefully.

Take the regular tablet with a cup of water.

To take the oral dissolving tablet (Zofran ODT):

• Place the tablet in the blister package until you are ready take it. Then, open the pack and peel off the foil. Be careful not to put a tablet in the foil as you could harm the tablet.
• Use dry hands to take off the tablet, then place it inside your mouth.
• Don’t swallow the tablet completely. Let it disintegrate in your mouth without chewing.
• Drink several times until the tablet disintegrates.

To use ondansetron oral soluble film (strip) (Zuplenz):

• Place this strip within the pouch made of foil till you’re ready to apply the medication.
• Utilizing dry hands, you can remove the strip from your hands and put the strip on top of your tongue. It will begin to break down in a matter of minutes.
• Do not ingest the entire strip. Allow it to dissolve into your mouth without chewing.
• Take a few breaths after the strip has disintegrated. If you wish, drink a liquid to aid in swallowing the strip after it has deteriorated.
• Cleanse your hands after using the Zuplenz.

Take measurements of liquid medicines using the dosing syringe with it, or use a dosing spoon or medicines cup. If you do not own a device for measuring doses, you can ask your pharmacist for one.

Keep at room temperature, free of heat, moisture, and light. Keep liquid medicine upright place.

If I do not take the dose?

You should take the missed dose as quickly as you can remember. Do not take your missed dosage if you are close to the time of the next dose. Don’t take any extra medication to make up for the missed dose.

How do I react if I consume too much?

For medical emergencies, seek emergency medical attention or contact the Poison Helpline toll-free at 1-800-222-1222.

Overdose symptoms can be sudden vision loss, extreme constipation, lightheadedness, or fainting.

What can you do to be aware of to

Ondansetron could affect your ability to think or react. Be cautious when you drive or perform any activity that requires you to be aware.

Ondansetron side effects

Take immediate medical attention if you show symptoms warnings of an allergy reaction to the Ondansetron: rash, hives, as well as chills, fever or breathing problems, or swelling of your lips, face, and tongue.

Consult your physician immediately if you are suffering from:

• extreme constipation and stomach pains, as well as excessive bloating;
• headache, chest pain, fainting, severe dizziness, rapid or pounding heartbeats;
• rapid heartbeats or fast beats;
• Jaundice (yellowing of the eyes or skin);
• blurred vision, or temporary vision loss (lasting between a few minutes up to more than a few hours);
• High serotonin levels within the body cause hallucinations, anxiety, fever, a fast heart rate, excessively active reflexes, nausea, vomiting, loss of coordination, diarrhea, and fainting.

Common side effects of Ondansetron be:

• constipation or diarrhea
• headache;
• Drowsiness or
• tired feeling.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Ondansetron side effects

Dosing information

Usual Adult Dose of Ondansetron for Nausea/Vomiting — Chemotherapy Induced:

Oral:

Highly Emetogenic Cancer Chemotherapy (HEC):

Recommended dose: 24 mg orally for 30 minutes before the day’s first single-day HEC (including doses of cisplatin of 50 mg/m2 or more)

Moderately Emetogenic Cancer Chemotherapy (MEC):

Recommended dose 8 mg every day, twice per day. The first dose is administered 30 minutes prior to the commencement of chemotherapy. The second dose 8 hours after followed by 8 mg taken orally twice a day (every 24 hours) for one to two days following the end of chemotherapy.

Parenteral:

The recommended dose is 0.15 mg/kg IV. This is followed by an initial dosage (infused for 15 mins) 30 minutes prior to the beginning of chemotherapy emetogenic. The doses to follow are between 4 and 8 hours following the initial amount.

-Maximum dose: 16 mg per dose

Comments:

A single dose administered over 24 hours 24 mg taken orally to treat HEC has not been investigated.

The formulation for injection is to be diluted prior to IV administration.

Uses:

-Prevention of vomiting and nausea caused by HEC or MEC

Preventing vomiting and nausea that can be caused by the initial and subsequent treatments of emetogenic chemotherapy

Usual Adult Dose of Ondansetron for Nausea/Vomiting:

Oral:

Highly Emetogenic Cancer Chemotherapy (HEC):

Recommended dose: 24 mg taken orally 30 mins before the day’s start for single-day HEC (including amounts that are 50 mg/m2 and higher)

Moderately Emetogenic Cancer Chemotherapy (MEC):

Dosage is recommended 8 mg twice daily, with the first dose being administered 30 minutes before the beginning of chemotherapy. The second dose 8 hours after and then 8 mg orally twice a day (every twelve hours) for up to 2 days following the end of chemotherapy.

Parenteral:

The recommended dose is 0.15 mg/kg IV. This is followed by one dosage (infused in 15 minutes) 30 minutes before emetogenic chemotherapy and then the doses to follow within 4 to 8 hours of the initial dose.

-Maximum dose: 16 mg per dose

Comments:

A single dose administered over 24 hours 24 mg taken orally to treat HEC has not been investigated.

The injection solution must be diluted prior to the administration of IV.

Uses:

-Prevention of vomiting and nausea caused by HEC or MEC

Prevention of nausea and vomiting that are associated with repeated and initial treatments of emetogenic chemotherapy

Usual Adult Dose of Ondansetron for Nausea/Vomiting — Postoperative:

Oral:

Recommended dose: 16 mg orally for 1 hour before the onset of anesthesia

Parenteral:

Recommended dose: 4 mg in IV (undiluted) immediately before starting anesthesia or after surgery (nausea or vomiting for 2 hours of surgery)

Alternate route 4 mg IM (undiluted)

Comment:

The administration of a dose in a subsequent dose does not give additional control over nausea or vomiting.

Use:

Preventing postoperative nausea and vomiting

Usual Adult Dose for Nausea/Vomiting–Radiation-Induced:

Dosage recommended: 8 mg orally, 3 times per day.

Total Body Irradiation 8 mg, orally 1 up to 2 hours prior to each radiotherapy fraction given each day

-Single High-dose Fraction radiotherapy to the abdomen 8 mg administered orally one to 2 hours prior to radiotherapy, and then doses every 8 hours following the first dose, for up to 2 days after the conclusion of radiotherapy

Fractionated Radiotherapy Daily for the Abdomen 8 mg taken orally one up to 2 hours prior to radiotherapy, with doses every 8 hours following the first dose of radiotherapy is administered every day.

Use:

Preventing nausea and vomiting that can be caused by radiotherapies, such as complete body irradiation, single high-dose fractions, or daily fractions of radiation to the abdomen

Usual Pediatric Dose for Nausea/Vomiting — Postoperative:

Parenteral:

One month up to twelve years old:

less than 40kg:

Recommended dosage: 0.1 mg/kg IV over 2 to 5 minutes following anesthesia induction or postoperatively (nausea or vomiting that may occur within a few minutes of surgery)

40 kg or more:

The recommended dose is 4 mg IV in 2 to 5 minutes following anesthesia induction or postoperatively (nausea and vomiting that may occur immediately following surgery)

Use:

-Prevention of nausea postoperatively and vomiting

Usual Pediatric Dose for Nausea/Vomiting — Chemotherapy Induced:

Oral:

Between 4 and 11 years old

The recommended dose is 4 mg, taken orally three times a day. With the first dose being administered 30 minutes prior to the commencement of chemotherapy. Then, follow-up doses every 4 or 8 hours following the initial dose. Then, 3 mg orally, three times every day (every eight hours) for the first to two days following the end of chemotherapy.

12-year-olds and over:

Recommended dose 8 mg, twice daily, with the first dose being administered 30 minutes prior to the commencement of chemotherapy. The second dose 8 hours after followed by 8 mg taken orally twice a day (every 24 hours) for up to 2 days following the conclusion of chemotherapy.

Parenteral:

From 6 months until 18 years old:

The recommended dose is 0.15 mg/kg IV. Take initial dosage (infused in 15 minutes) 30 minutes prior to the beginning of chemotherapy with emetogenic agents and the subsequent doses administered between 4 and 8 hours following the first dose.

-Maximum dose: 16 mg (per dose)

Comments:

The formulation for injection must be dilute to 50 mL prior to the IV administration.

The drug is intended to reduce nausea and vomiting caused by moderately to highly emetogenic chemotherapy.

Uses:

Preventing nausea and vomiting that is associated chemotherapy for moderately emetogenic cancers.

Preventing nausea and vomiting that is associated with repeated and initial courses of chemotherapy emetogenic

Detailed Ondansetron dosage information

What other medications can affect Ondansetron?

Ondansetron can trigger a serious heart issue, particularly if you take certain medications in conjunction, including antidepressants, antibiotics and heart rhythm medicines, antipsychotic medications, and other medicines to treat malaria, cancer, HIV, or AIDS. Inform your doctor about the drugs you take and the medicines you take or stop taking during the treatment you receive with Ondansetron.