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Cafergot (Ergotamine with Caffeine)

Active Ingredient: Ergotamine 1mg  and Caffeine 100mg
Manufacturer: Amdi Pharm
Drug Type: Alkaloids

Cafergot, Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural similarity to several neurotransmitters and has biological activity as a vasoconstrictor. It is used medicinally for the treatment of acute migraine attacks.


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Buy Cafergot Online For Migraine

What is Cafergot?

Caffeine (Cafergot) is a stimulant that causes the narrowing of blood vessels (vasoconstriction).

Cafergot is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Cafergot also affects blood flow patterns that are associated with certain types of headaches.

Cafergot is a combination medicine used to treat or prevent a migraine type of headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Cafergot should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Cafergot may also be used for purposes not listed in this medication guide.

Cafergot indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Preventing and treating certain kinds of headaches (eg, migraines, migraine variants, “histaminic cephalalgia”). It may also be used for other conditions as determined by your doctor.

Cafergot is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches.

How should I use Cafergot?

Use Cafergot suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cafergot suppositories may be taken with or without food.
  • Eating grapefruit or drinking grapefruit juice may affect the amount of Cafergot suppositories in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
  • Cafergot suppositories is only to be used as needed for a migraine attack.
  • Use Cafergot suppositories at the first sign of a headache. Remove the wrapper and moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum, then use your finger to push it in completely. Wash your hands thoroughly after using Cafergot suppositories.
  • If the suppository has softened because of a period of unavoidable exposure to heat, place in the refrigerator for about 15 minutes or chill in ice cold water before removing the wrapper.
  • If the initial dose does not relieve your headache, an additional dose may be needed according to your doctor’s instructions. Do not use a dose of Cafergot suppositories within 1 hour of your last dose.
  • Do not use more than 2 suppositories for a single migraine headache or more than 5 suppositories during any 7-day period without first checking with your doctor.
  • If you miss a dose of Cafergot suppositories and you still have a headache, use it as soon as you remember. Do not use a dose of Cafergot suppositories within 1 hour of your last dose. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cafergot suppositories.

Uses of Cafergot in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This combination medication is used to treat or prevent certain types of headaches (vascular headaches including migraine and cluster headaches). Headache pain can sometimes be caused by widened blood vessels in the head. Cafergot works by narrowing these widened blood vessels. Caffeine (Cafergot) increases the absorption of Cafergot and also narrows widened blood vessels.

How to use Cafergot

Take this medication by mouth with or without food as directed by your doctor, usually 2 tablets at the first sign of headache, followed by 1 tablet every half hour until the headache is relieved. Do not take more than 6 tablets per headache attack or 10 tablets in a 7-day period.

If your doctor has prescribed this medication to help prevent certain types of headaches (such as cluster headaches), take this medication exactly as directed by your doctor, usually for short-term treatment (2 to 3 weeks).

The dosage is based on your medical condition and response to treatment. This medication works best if it is taken at the first sign of the headache. If you wait until the headache has worsened, the medication may not work as well.

If you have a higher risk for heart problems, your doctor may perform a heart exam before you start taking this medication. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain). Talk to your doctor for details.

This medication is usually taken only as needed. It is not meant for long-term daily use.

Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.

Overuse of drugs to treat sudden migraine attacks can sometimes lead to worsening of headache (medication overuse headache) or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches. Your doctor may need to change your medication and/or add another medication to help prevent headaches.

Cafergot description

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Cafergot&

Cafergot dosage

For the best results, dosage should start at the first sign of an attack.



CYP 3A4 Inhibitors (e.g., Macrolide Antibiotics and Protease Inhibitors): See CONTRAINDICATIONS and WARNINGS.

CAFERGOT® (Cafergot tartrate and Caffeine (Cafergot) tablets, USP) should not be administered with other vasoconstrictors. Use with sympathomimetics (pressor agents) may cause extreme elevation of blood pressure. The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of CAFERGOT® (Cafergot tartrate and Caffeine (Cafergot) tablets, USP) by blocking the vasodilating property of epinephrine. Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.

The blood levels of Cafergot-containing drugs are reported to be elevated by the concomitant administration of macrolide antibiotics and vasospastic reactions have been reported with therapeutic doses of the Cafergot-containing drugs when coadministered with these antibiotics.

Cafergot side effects

What are the possible side effects of Cafergot?

Cardiovascular: Vasoconstrictive complications of a serious nature may occur at times. These include ischemia, cyanosis, absence of pulse, cold extremities, gangrene, precordial distress and pain, EKG changes and muscle pains. Although these effects occur most commonly with long-term therapy at relatively high doses, they have also been reported with short-term or normal doses. Other cardiovascular adverse effects include transient tachycardia or bradycardia and hypertension.

Gastrointestinal: Nausea and vomiting.

Neurological: paresthesias, numbness, weakness, and vertigo.

Allergic: Localized edema and itching.

Fibrotic Complications.

Drug Abuse And Dependence: There have been reports of drug abuse and psychological dependence in patients on CAFERGOT® (Cafergot tartrate and Caffeine (Cafergot)) (Cafergot tartrate and Caffeine (Cafergot) tablets, USP) therapy. Due to the chronicity of vascular headaches, it is imperative that patients be advised not to exceed recommended dosages with long-term use to avoid ergotism.

Cafergot contraindications

What is the most important information I should know about Cafergot?

Coadministration of Cafergot with potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin) has been associated with acute ergot toxicity (ergotism) characterized by vasospasm and ischemia of the extremities, with some cases resulting in amputation. There have been rare reports of cerebral ischemia in patients on protease inhibitor therapy when CAFERGOT® (Cafergot tartrate and Caffeine (Cafergot)) (Cafergot tartrate and Caffeine (Cafergot) tablets, USP) was coadministered, at least one resulting in death. Because of the increased risk for ergotism and other serious vasospastic adverse events, Cafergot use is contraindicated with these drugs and other potent inhibitors of CYP 3A4 (e.g., ketoconazole, itraconazole).

CAFERGOT® (Cafergot tartrate and Caffeine (Cafergot) tablets, USP) may cause fetal harm when administered to pregnant women. CAFERGOT® (Cafergot tartrate and Caffeine (Cafergot)) (Cafergot tartrate and Caffeine (Cafergot) tablets, USP) is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy or if the patient becomes pregnant while taking this product, the patient should be apprised of the potential hazard to the fetus.

Peripheral vascular disease, coronary heart disease, hypertension, impaired hepatic or renal function, and sepsis.

Hypersensitivity to any of the components.

Active ingredient matches for Cafergot:

Ergotamine for sale here

Caffeine/Ergotamine in Argentina, Australia, Bahrain, Belgium, Canada, Colombia, Greece, Indonesia, Israel, Italy, Japan, Malta, Netherlands, New Zealand, Oman, South Africa, Spain, Switzerland, Thailand, Turkey, United Kingdom, United States.

Active ingredient matches for Cafergot:

Caffeine/Ergotamine in Argentina, Australia, Bahrain, Belgium, Canada, Colombia, Greece, Indonesia, Israel, Italy, Japan, Malta, Netherlands, New Zealand, Oman, South Africa, Spain, Switzerland, Thailand, Turkey, United Kingdom, United States.

Caffeine/ergotamine tartrate in Singapore.

Ergotamine in Bahrain.

Caffeine/Caffeine Suppositories/ergotamine/Ergotamine Tartrate

Headache medicine ergot-derivative-containing

Unit description / dosage (Manufacturer)Price, USD Suppositories; Rectal; Caffeine 100 mg; Ergotamine Tartrate 2 mg Tablet; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg Cafergot 10 x 10’s Cafergot 100’s 12 suppository in 1 box Cafergot 10 x 10’s$ 82.62 Cafergot tab 100’s (Amdipharm) Cafergot tab 10 x 10’s (Amdipharm) Cafergot tab 20’s (A. Menarini)

List of Cafergot substitutes (brand and generic names):

Cafegotamine (Taiwan) Cafegotamine 1000’s Cafergot N Cafergot oral/rectal Cafergot Suppositories Cafergot Tablets Cafeton (Taiwan) Cafeton 1 mg Cafetrate caffeine and ergotamine caffeine and ergotamine oral/rectal Caffeine/ ergotamine Caffeine/ ergotamine suppositories Caffeine/ ergotamine Caffeine/ ergotamine suppositories Caffeine/Ergotamine (Argentina, Australia, Belgium, Canada, Colombia, Greece, Indonesia, Israel, Italy, Japan, Malta, Netherlands, New Zealand, Oman, South Africa, Spain, Switzerland, Thailand, Turkey, United Kingdom, United States) Caffeine/Ergotamine Suppositories Caffeine/ergotamine tartrate (Singapore) Caffox (Singapore) Caffox 50 x 10’s Clavigrenin Akut Coffecorn (Poland) Coffecorn Forte (Poland) Coffecorn Mite (Poland) Coffegot (Taiwan) Coffegot 1 mg Coffergamin (Bulgaria) Degran (Thailand) Degran 100’s (Ranbaxy) Degran tab 100’s (Ranbaxy) Enxak (Brazil) Ercaf ERGACAP ERGACAP 214MG CAPSULE 1 strip / 15 capsules each (Mercury Healthcare Pvt Ltd)$ 1.07 ERGACAP 214MG CAPSULE 1 strip / 20 capsules each (Mercury Healthcare Pvt Ltd)$ 0.97 Ergam (Hungary) Ergam 600 µg/ml (Hungary) Ergate Ergo Sanol SL Ergo Sanol Spezial N Ergo-Caff Dragee; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg Ergo-Kranit (Germany) Ergo-Kranit Akut Ergo-Kranit Migräne (Germany) Ergo-Kranit Migrane (Germany) Ergocaf (Mexico) Dragee; Oral; Caffeine 100 mg; Ergotamine Tartrate 1 mg Ergocafe (Taiwan) Ergocafe 100’s See 139 substitutes for Cafergot


  1. DailyMed. “CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).”. https://dailymed.nlm.nih.gov/dailyme…
  2. PubChem. “ERGOTAMINE”. https://pubchem.ncbi.nlm.nih.gov/com…
  3. PubChem. “caffeine”. https://pubchem.ncbi.nlm.nih.gov/com…

More about Cafergot

Read more about Ergotamine here

We ship from several different shipping locations around the world. We always choose the best one for the customer's shipping destination based on our long experience to make the parcel reach the customer as fast and secure as possible.

Here are some average delivery times and shipping locations.shipping and delivery

From Avg. Delivery Dispatch Time
India 7-14 days 1-3 days
Singapore 7-20 days 1-3 days
Philippines 7-14 days 1-4 days
USA Domestic 2-5 days 1-5 days
Europe to Europe 3-7 days 1-3 days
  1. For the more popular products, we ship US to the US, from our shipping locations within the USA, shipments usually take 5 days.
  2. Europe's deliveries are typically made from Germany, Greece, and the Netherlands. If you live in Germany, your order will be automatically shipped from Germany; if you live in another EU country, your order will be shipped from the Netherlands; both will receive tracking within 1-3 business days.


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